Sluggy Freelance by Pete Abrams
Let me explain... no, there is too much... let me sum up. A freelance web designer, his cannibalistic alien receptionist, a homicidal mini-lop-eared rabbit named Bun-Bun, an inventor with a penchant for large laser cannons, vampires, time travel, unearthly monsters and a coupl'a babes. What more could you ask for?
The Mr. Chuck Show by John Myers
The Mr. Chuck Show is a full-color comic strip that is 24.85% madcap adventures, 48.13% wacky situations. and 27.02% zany hijinks. Confused by math? Then just think of it as "The Muppets on Crack"! What are you waiting for?
Heart of the City by Mark Tatulli
Heart and her mom live in Philly. This is a very funny strip with great art and it's creator is very friendly and supportive to upcoming cartoonists.
Buckles by David Gilbert
Proves that a kid from Upstate New York can make it in this business.